Virtually all causes of human morbidity and mortality are associated with changes in tissue architecture. Accordingly, the long-term goal of this work is to provide a foundation for comparing phenotypes across model systems using human tissue architecture as an anchor. Tissue architecture provides context for molecular mechanisms. Good models of human disease show comparable patterns of change.

Scans of human slides began with Fred Dee's collection at University of Iowa. We are now adding more from Penn State, and enthusiastically invite collaborations to incorporate high-quality slide sets from other institutions. Contributors will be given proper academic or other credit by citation within the web site.

zebrafish tissue section


Virtual slide technology enables users to view high resolution imagery with a significantly reduced download time. Virtual slides are panned and zoomed in a manner similar to a traditional microscope but offer labeling, comparison, and collaborative possibilities beyond the limitations of physical microscopy. We now seek contributions of high-resolution, high-quality 2D and 3D images for inclusion in this resource.